New Dipeptides Containing Thiazolidine-4-carboxylic Acid Derivatives : Synthesis and Characterization Using NMR Techniques and X-Ray Data

概要

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New dipeptides, structural analogues of known immunomodulating agents, were prepared by stereospecific condensation between 2-substituted thiazolidine-4-carboxylate esters with N-substituted L-proline or L-thiaproline. The structure of these compounds has been elucidated by combination of NMR methods and X-ray analysis. In addition, NMR measurements on dipeptides indicated the presence of S-cis and S-trans conformers around the amide bonds.
公益社団法人日本薬学会の論文
1999-07-15