The Antimalarial Agent Halofantrine Perturbs Phosphatidylcholine and Phosphatidylethanolamine Bilavers : a Differential Scanning Calorimetric Study
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概要
- 論文の詳細を見る
The interaction of halofantrine with phosphatidylcholine and phosphatidylethanolamine bilayers has been investigated by differential scanning calorimetry. Halofantrine caused a broadening of the gel to liquid crystalline phase transition endotherm of the phosphatidylcholines. A decrease in the transition temperature T_m and enthalpy (ΔH) of transition was also observed. The varied with the chain length of the phospholipid and was more pronounced with short cahain members. Halofantrine-induced changes to the thermotropic characteristics of dipalmitoylphosphatidylcholine (DPPC)/cholesterol bilayers suggested that the penetration of halofantrine into the bilayer was diminished in the presence of cholesterol. A more complex calorimetric profile was observed in the intetaction of halofantrine with phosphatidylethanolamines and the results suggested that halofantrine did not disrupt the cooperativity of the phosphatidylethanolamine bilayers to the same extent as that observed with the phosphatidylcholines. Halofantrine caused significant perturbation of phospholipids and this property might have an important bearing on its pharmacodynamic effects.
- 公益社団法人日本薬学会の論文
- 1999-06-15
著者
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Lim L‐y
National Univ. Singapore Singapore
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Go Mei-lin
Department Of Pharmacy National University Of Singapore
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LIM Lee-Yong
Department of Pharmacy, National University of Singapore
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Lim Lee-yong
Department Of Pharmacy National University Of Singapore
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