Synthesis and Biological Evaluation of 5-Arylfuro[2,3-d]pyrimidines as Novel Dihydrofolate Reductase Inhibitors

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概要

• 論文の詳細を見る

• A series of about fifty novel 5-arylfuro[2,3-d]pyrimidine derivatives were synthesized as potential inhibitors of dihydrofolate reductase (DHFR) arising from different species. Weak enzyme inhibition was observed for most of the compounds, with only a few reaching IC_<50> values less than 30 μM. With regards to antibacterial and antimalarial potency, only seven compounds showed a modest in vitro activity against some bacterial strains and only three products proved significantly active against P. falciparum.

• 公益社団法人日本薬学会の論文
• 1999-02-15

著者

• Monneret Claude

  Unite Mixte De Recherche Institut Curie-cnrs (umr176) Institut Curie Section De Recherche

• Dauzonne Daniel

  Unite Mixte De Recherche Institut Curie-cnrs (umr176) Institut Curie Section De Recherche

• WAHID Farid

  Unite Mixte de Recherche Institut Curie-CNRS (UMR176), Institut Curie, Section de Recherche

• Wahid Farid

  Unite Mixte De Recherche Institut Curie-cnrs (umr176) Institut Curie Section De Recherche

関連論文

• Synthesis and Biological Evaluation of Flavanones and Flavones Related to Podophyllotoxin
• Synthesis and Biological Evaluation of 5-Arylfuro[2,3-d]pyrimidines as Novel Dihydrofolate Reductase Inhibitors

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