Synthesis and Biological Activity of N-(Aminoiminomethyl)-1H-indole Carboxamide Derivatives as Na^+/H^+ Exchanger Inhibitors
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概要
- 論文の詳細を見る
A series of N-(aminoiminomethyl)-1H-indole carboxamide derivatives were synthesized and their inhibitory potencies against the Na^+/H^+ exchanger were measured. Variation of the carbonylguanidine group at the 2- to 7-position of the indole ring system showed that a substitution at the 2-position improved the Na^+/H^+ exchanger inhibitory activity the most in vitro. This led to the synthesis and evaluation of an extensive series of N-(aminoiminomethyl)-1H-indole-2-carboxamide derivatives. Derivatives having an alkyl or substituted alkyl group at the 1-position of the indole ring system showed higher levels of in vitro activities. N-(aminoiminomethyl)-1-(2-phenylethyl)-1H-indole-2-carboxamide (49) had the strongest activity.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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Miyagishi Akira
Research Center Sumitomo Pharmaceuticals Co. Ltd
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Noguchi Tsuyoshi
Research Center Sumitomo Pharmaceuticals Co. Ltd
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OHASHI Naohito
Research Center, Sumitomo Pharmaceuticals Co., Ltd.,
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Ohashi N
Discovery Research Laboratories I Research Center Sumitomo Pharmaceuticals Co. Ltd
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Ohashi N
Sumitomo Pharmaceuticals Research Division
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Ohashi Naohito
Research Center Sumitomo Pharmaceuticals Co. Ltd
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Kitano M
Research Center Sumitomo Pharmaceuticals Co. Ltd
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小島 淳之
Sumitomo Pharmaceuticals Research Center
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KITANO Masafumi
Research Center, Sumitomo Pharmaceuticals Co., Ltd
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KOJIMA Atsuyuki
Research Center, Sumitomo Pharmaceuticals Co., Ltd
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NAKANO Kazuhiro
Research Center, Sumitomo Pharmaceuticals Co., Ltd
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Nakano K
Research Center Sumitomo Pharmaceuticals Co. Ltd
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Kojima A
Research Center Sumitomo Pharmaceuticals Co. Ltd
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