Investigation of the Microprecipitation of Folic Acid from Slightly Acidic Injection Solutions Using Dynamic Light Scattering

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概要

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• Microprecipitation of folic acid was monitored by the dynamic light scattering (DLS) method. The pH was changed by CO_2 absorption and addition of HCl. The folic acid solutions were examined over the pH range 8.5-4.0. Over the pH range 5.4-6.0,microprecipitation was observed and at pH ≤5.2 crude precipitation of folic acid occurred. The dependence of the effective diameter on the pH over the pH range 5.4-6.0 is also reported.

• 公益社団法人日本薬学会の論文
• 1998-08-15

著者

• Deak G

  Univ. Debrecen Debrecen Hun

• Deak Gyorgy

  Department Of Applied Chemistry University Of Debrecen Medical And Health Science Center

• KEKI Sandor

  Department of Applied Chemistry, Lajos Kossuth University

• SIPOS Tamas

  Department of Pharmaceutical Technology, Lajos Kossuth University

• MEZEY Geza

  Department of Pharmaceutical Technology, Lajos Kossuth University

• ZSUGA Miklos

  Department of Applied Chemistry, Lajos Kossuth University

• Mezey Geza

  Department Of Pharmaceutical Technology Lajos Kossuth University

• Keki S

  Univ. Debrecen Debrecen Hun

• Sipos Tamas

  Department Of Pharmaceutical Technology Lajos Kossuth University

• Zsuga M

  Univ. Debrecen Debrecen Hun

• Keki Sandor

  Department Of Applied Chemistry University Of Debrecen

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• Investigation of the Microprecipitation of Folic Acid from Slightly Acidic Injection Solutions Using Dynamic Light Scattering
• Synthesis and antimicrobial activity of ciprofloxacin and norfloxacin permanently bonded to polyethylene glycol by a thiourea linker

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