Antibacetrials and Antimycotics : Part 1 : Synthesis and Activity of 2-Pyrazoline Derivatives

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概要

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• A series of 3-styryl-1,5-diphenyl and 5-styryl-1,3-diphenyl 2-pyrazolines of different substitutions has been synthesized by condensation of substituted α, β-unsaturated ketones with phenylhydrazine hydrochloride in presence of catalytic amount of concentrated HCl. Compounds in the 3-styryl series had OMe, NMe_2,NO_2,OH and isopropyl substituents and those in the 5-styryl series had OMe, NMe_2 and NO_s. The 3-styryl-1,5-diphenyl compounds showed little variation in antibacterial activity towards gram-positive and gram-negative bacteria in terms of geometric mean minimum inhibitory concentrations (MIC). The 4', 4''-NMe_2,4', 4''-NO_2 and 4', 4''-OMe compounds were found to possess the highest activity in the series. The 5-styryl-1,3-diphenyl series showed lower activities than the 3-styryl series. The in vitro antimycotic activity of the 4', 4''-OH and 2', 2''-OH substituted compounds showed good activity than the other molecules in the two series.

• 公益社団法人日本薬学会の論文
• 1998-08-15

著者

• Reddy Gopu

  Department Of Pharmaceutical Sciences Andhra University

• Nauduri Dhananjaya

  Department Of Organic Chemistry Andhra University

関連論文

• Antibacetrials and Antimycotics : Part 1 : Synthesis and Activity of 2-Pyrazoline Derivatives

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