Practical Synthesis of 1β-Methylcarbapenem Antibiotics : Side-Chain Substitution Reaction of 2-Arylsulfinyl and 2-Arylsulfonyl Carbapenems

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概要

• 論文の詳細を見る

• The C-2 side-chain substitution reaction of a sulfoxide and a sulfone derived from a p-nitrobenzyl (1R, 5S, 6S)-6-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-[2-(diethylcarbamoyl)phenylthio]-1-methylcarbapen-2-em-3-carboxylate with various mercaptans progressed smoothly in the presence of magnesium bromide. Bromomagnesium thiolate prepared from mercaptans proved to be especially effective for the substitution reaction and gave precursors of 1β-methylcarbapenem antibiotics in high yield.

• 公益社団法人日本薬学会の論文
• 1998-06-15

著者

• Oda Kozo

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

• YOSHIDA Akira

  Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd.,

• Yoshida Akira

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

関連論文

• Practical Synthesis of 1β-Methylcarbapenem Antibiotics : Side-Chain Substitution Reaction of 2-Arylsulfinyl and 2-Arylsulfonyl Carbapenems
• A Practical and Stereocontrolled Synthesis of a Versatile 1β-Methylcarbapenem Intermediate

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