Interaction of Amiodarone and Desethylamiodarone with Dimyristoyl Phosphatidylcholine Bilayers

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概要

• 論文の詳細を見る

• The interaction between amiodarone or desethylamiodarone and dimyristoyl phosphatidylcholine bilayers was investigated by two optical techniques, quasi-elastic light scattering (QLS) and Fourier transform infrared spectroscopy (FT-IR). The results show that in th presence of the drugs, the bilayer phase transition point is lowered and at high drug concentration there is an incresase in the vesicle size. The FT-IR results indicate interactions in the hydrocarbon region and also in the carbonyl interface region of the bilayers. There may be an interdigitation of two leaflets of the bilayer. We discussed these results comparatively with those obtained from propranolol whose effect was analogous and previously studied.

• 公益社団法人日本薬学会の論文
• 1997-08-15

著者

• Cao Xuan

  Laboratoire De Spectroscopie Biomoleculaire Cnrs Ura N° 1430

• Perret Gerard

  Laboratoire De Pharmacologie Ufr De Medecine Et Biologie Humaine Universite Paris Xiii

• ATTAL Yasser

  Laboratoire de Spectroscopie Biomoleculaire CNRS URA n° 1430

• TAILLANDIER Eliane

  Laboratoire de Spectroscopie Biomoleculaire CNRS URA n° 1430

関連論文

• Interaction of Amiodarone and Desethylamiodarone with Dimyristoyl Phosphatidylcholine Bilayers

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