Nucleophilic Reactions on 1-Trifluoromethanesulfonylpyridinium Trifluoromethanesulfonate (Triflypyridinium Triflate, TPT).Ring-Opening and "Unexpected" 1,4-Dihydropyridine Reaction Products

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概要

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• The reaction products of 1-trifluoromethanesulfonylpyridinium trifluoromethanesulfonate (TPT) with secondary amines have been thoroughly examined by spectroscopic and X-ray diffraction methods. The products include the normal ones expected for a ring-opening reaction (1-azahexatriene and cyanine) in addition to the "unexpected"formation of a 4-substituted 1,4-dihydropyridine. Tandem reactions -ring-opening, nucleophilic addition- on the pyridinium ring seems to be the most probable pathway to the 1,4-dihydropyridine compounds. Preliminary tests on the compounds revealed significant anti-microbial activity against Gram-positive bacteria, with moderate specificity towards Enterococcus faecalis.

• 公益社団法人日本薬学会の論文
• 1997-06-15

著者

• Toscano Ruben

  Instituto De Quimica Universidad Nacional Autonoma De Mexico Circuito Exterior Ciudad Universitaria

• Rio Portilla

  Instituto De Quimica Universidad Nacional Autonoma De Mexico Circuito Exterior Ciudad Universitaria

• Hernandez-galindo Maria

  Instituto De Quimica Universidad Nacional Autonoma De Mexico Circuito Exterior Ciudad Universitaria

• Alvarez-toledano Cecilio

  Instituto De Quimica Universidad Nacional Autonoma De Mexico Circuito Exterior Ciudad Universitaria

• ROSAS Raul

  Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitar

• GARCIA-MELLADO Olivia

  (Present address)Facultad de Estudios Superiores Cuautitlan, UNAM

• AMABILE-CUEVAS Carlos

  (Present address)Departamento de Famacologia, Facultad de Medicina

• Rosas Raul

  Instituto De Quimica Universidad Nacional Autonoma De Mexico Circuito Exterior Ciudad Universitaria

• Garcia-mellado Olivia

  (present Address)facultad De Estudios Superiores Cuautitlan Unam

• Amabile-cuevas Carlos

  (present Address)departamento De Famacologia Facultad De Medicina

• Toscano Ruben

  Instituto De Quimica Universidad Nacional Autonoma De Mexico

関連論文

• Nucleophilic Reactions on 1-Trifluoromethanesulfonylpyridinium Trifluoromethanesulfonate (Triflypyridinium Triflate, TPT).Ring-Opening and "Unexpected" 1,4-Dihydropyridine Reaction Products
• A Precursor of the Natural Product 5, 7-Dihydroxy-4, 6-dimethyl-1(3H)-isobenzofuranone : Crystal and Molecular Structure of 6-Carbomethoxy-4-formyl-2-methyl-5-pivaloyloxymethyl-1, 3-benzenediol
• Crystal and Molecular Structures of the Methyl Ester of the 3-Formyl-4,6-dihydroxy-5-isopropyl-2-methylbenzoic Acid: a Synthetic Intermediate to the Espintanol
• Crystal Structure of 2, 4-Carbomethoxy-3, 5-biphenyldiol

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