Biomimetic Oxidation of 2-Methylimidazole Derivative with a Chemical Model System for Cytochrome P-450

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概要

• 論文の詳細を見る

• A chemical model system for cytochrome P-450, consisting of tetraphenylporphyrin manganese chloride (TPPMnCl) and iodosylbenzene, efficiently oxidized 2-methylimidazole to 2-methylimidazolone. This system was next applied to 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutyramide, a muscarinic acetylcholine receptor antagonist under clinical trial, affording the previously unisolated imidazole ring 5-mono-oxidized derivative that is considered to be the precursor of the main metabolites. This system, which is superior to the copper-ascorbate system, should be applicable to in vitro studies of various drugs containing the 2-methylimidazole moiety.

• 公益社団法人日本薬学会の論文
• 2002-08-01

著者

• Miyachi Hiroyuki

  Discovery Research Laboratories Kyorin Pharmaceutical Co. Ltd.

• Nagatsu Y

  Discovery Research Laboratories Kyorin Pharmaceutical Co. Ltd.

• NAGATSU Yoshio

  Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd.

関連論文

• Molecular Modeling Study of Species-Selective Peroxisome Proliferator-Activated Receptor (PPAR) α Agonist ; Possible Mechanism(s) of Human PPARα Selectivity of an α-Substituted Phenylpropanoic Acid Derivative (KCL)
• Biomimetic Oxidation of 2-Methylimidazole Derivative with a Chemical Model System for Cytochrome P-450

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