Total Synthesis and Biosynthesis of the Paraherquamides : An Intriguing Story of the Biological Diels-Alder Construction
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概要
- 論文の詳細を見る
The syntheses and biosyntheses of the paraherquamide and brevianamide families of prenylated indole-derived alkaloids are reviewed. It has been proposed that the unique bicyclo[2.2.2]diazaoctan ring system that is common to this family of natural products, arises by a biological intramolecular Diels-Alder cycloaddition reaction. Both synthetic approaches and total syntheses of several members of this family of natural products are reviewed. The biosynthesis of these alkaloids has also constituted an active area of research and the current state of knowledge on the biosynthesis of these natural products are reviewed.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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Williams R
Colorado State Univ. Colorado
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Williams Robert
Contribution From The Department Of Chemistry Colorado State University