Pd Asymmetric Allylic Alkylation(AAA). : A Powerful Synthetic Tool

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概要

• 論文の詳細を見る

• Palladium catalyzed asymmetric allylic alkylations represent a challenging probiem because the mechanism of the reaction places the chiral environment distal to the bond breaking or making events responsibie for the asymmetric induction. Furthermore, unlike virtually every other asymmetric process, many strategies can be employed for introduction of asymmetry and many different types of bonds can be formed. While oven 100 different ligands have been designed, a family of ligands derived from 2-diphenylphosphinobenzoic or 1-naphthoic acid and chiral scalemic diamines have been successful in inducing excellent enantioselectivity by five different enantiodiscriminating events. These methods have already provided practical strategies towards numerous biological targets-some of which are adenosine and its enantiomer, aflatoxin B, aristeromycin, calanolide A and B, carbovir, cyclophellitol, ethambutol, galanthamine, mannostatin, neplanocin, phyllanthocin, sphingofungins E and F, tetraponaines, vigabatrin, and valienamine.

• 公益社団法人日本薬学会の論文
• 2002-01-01

著者

• Trost Barry

  Department Of Chemistry Stanford University

関連論文

• Pd-Catalyzed Cycloaddition of Vinylcyclopentenes with Trimethylenemethane. Substituent Effent on [4+3] vs [3+2] Selectivity
• Pd Asymmetric Allylic Alkylation(AAA). : A Powerful Synthetic Tool

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