Carbon Disulfide Promoted Reactions of 2-Chloro-4, 5-dihydro-imidazole with Some N-Nucleophiles

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概要

• 論文の詳細を見る

• The reactions of 2-chloro-4, 5-dihydroimidazole 1 with o-substituted anilines and azoles promoted by carbon disulfide have been carried out. Ab initio MO calculations were used to elucidate the mechanism of the reaction of 1 with N-nucleophilic reagents. A facile synthesis of 2-(4, 5-dihydroimidazol-2-yl)-lH-indazole 3e bearing structural resemblances to 2-BFI, a potent and selective agonist of imidazoline I_2 receptors, is also described. Structure of 3e was confirmed by NMR spectroscopy and X-ray analysis.

• 公益社団法人日本薬学会の論文
• 2001-09-01

著者

• Gdaniec Maria

  Faculty Of Chemistry A.mickiewicz University

• SACZEWSKI Franciszek

  Department of Chemical Technology of Drugs, Medical University of Gdansk

• SACZEWSKI Jaroslaw

  Department of Chemical Technology of Drugs, Medical University of Gdansk

• Saczewski F

  Department Of Chemical Technology Of Drugs Medical University Of Gdansk

• Saczewski Jaroslaw

  Department Of Chemical Technology Of Drugs Medical University Of Gdansk

• Gdamiec Maria

  Faculty of Chemistry, A.Mickiewicz University

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• Carbon Disulfide Promoted Reactions of 2-Chloro-4, 5-dihydro-imidazole with Some N-Nucleophiles

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