Studies on New Platelet Aggregation Inhibitors 1. Synthesis of 7-Nitro-3, 4-dihydroquinoline-2(1H)-one Derivatives

スポンサーリンク

概要

• 論文の詳細を見る

• A series of 6-cyclic aliphatic amino-7-nitro-3, 4-dihydroquinoline-2(1H)-ones were prepared and tested for platelet aggregation inhibitory effect, cardiotonic activity and chronotropic activity. These compounds appeared to show selective inhibitory activity against platelet aggregation. Among them, 6-(4-ethoxycarbonylpiperidino)-7-nitro-3, 4-dihydroquinoline-2(1H)-one (22f) showed the most potent inhibitory activity and high selectivity. A divergent synthetic route to 6-cyclic aliphatic amino-7-nitro-3, 4-dihydroquinoline-2(1H)-one derivatives has also been investigated.

• 公益社団法人日本薬学会の論文
• 2001-07-01

著者

• Kusama Hiroshi

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Harada Hiromu

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.

• Harada Hiromu

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• IYOBE Akira

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• UCHIDA Masahiko

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• KAMATA Kouji

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• HOTEI Yukihiko

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

• Iyobe A

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Kamata K

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Hotei Yukihiko

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Uchida Masahiko

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• KUSAMA Hiroshi

  Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.,

関連論文

• Discovery of Novel 2-Anilinopyrazolo[1,5-a]pyrimidine Derivatives as c-Src Kinase Inhibitors for the Treatment of Acute Ischemic Stroke
• CANINE CORONARY REPERFUSION MODEL AND THE INFLUENCE OF OKY-046, A SPECIFIC TXA_2 SYNTHETASE INHIBITOR : Ischemic Heart Disease (II), Coronary Circulation : II : 48 Annual Scientific Meeting, Japanese Circulation Society
• Renin Inhibitors Designed on the Basis of Angiotensinogen Transition-State
• Studies on New Platelet Aggregation Inhibitors 1. Synthesis of 7-Nitro-3, 4-dihydroquinoline-2(1H)-one Derivatives
• Mechanism f inhibitory action of tranilast on the release of slow reacting substance of anaphylaxis (SRS-A) in vitro: Effect of tranilast on the release of arachidonic acid and its metabolites.
• Study of the mechanism of inhibitory action of tranilast on chemical mediator release.

スポンサーリンク