Synthesis and Anti-influenza Virus Activity of Tricyclic Compounds with a Unique Amine Moiety

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概要

• 論文の詳細を見る

• Several novel tricyclic compounds with a unique amine moiety(1, 2a-i)were designed and prepared based on the structure of triperiden for the development of anti-influenza virus agents. An in vitro antiviral assay showed that 1-(1-azabicyclo[3.3.0]octan-5-yl)-1-(4-fluorophenyl)-1-(2-tricyclo[3.3.1.1^<3, 7>]decyl)methan-1-ol hydrochloride(2f)has a potent anti-influenza A virus activity. Furthermore, since 2f was well tolerated in mice, 2f is promising as a novel anti-influenza virus agent for humans.

• 2001-04-01

著者

• Honda Naoki

  Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Ishiwata Yoshiro

  Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Iwata Noriyuki

  Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Kakigami T

  Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• OKA Mitsuru

  Central Research Laboratory, Sanwa Kagaku Kenkyusho, Co., Ltd.

• KAKIGAMI Takuji

  Central Research Laboratory, Sanwa Kagaku Kenkyusho, Co., Ltd.

• Oka M

  Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

• Oka Mitsuru

  Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.

関連論文

• Synthesis and Anti-influenza Virus Activity of Tricyclic Compounds with a Unique Amine Moiety
• Synthesis of 1-Azabicyclo[3.3.0]octane Derivatives and Their Effects as Piracetam-like Nootropics

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