Structure-Activity Relationships for a Collection of Structurally Diverse Inhibitors of Purine Nucleoside Phosphorylase

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概要

• 論文の詳細を見る

• Values of inhibition constants, K_i, and concentrations required for 50% inhibition, IC_<50> for a collection of structurally diverse competitive inhibitors of calf spleen purine nucleoside phosphorylase have been determined employing inosine as substrate. These values have been employed to create predictive quantitative structure-activity relationships(QSAR)which link structure to values of K_i and IC_<50>. These QSAR models have substantial power to predict values and the associated uncertainties for K_i and IC_<50> for unknown, structurally diverse inhibitors of purine nucleoside phosphorylase.

• 公益社団法人日本薬学会の論文
• 2001-01-01

著者

• Yunes R

  Federal De Santa Catarina

• Yunes Rosendo

  Federal De Santa Catarina

• ANDRICOPULO Adriano

  College of Pharmacy, University of Michigan

• Andricopulo Adriano

  College Of Pharmacy University Of Michigan

関連論文

• Structure-Activity Relationships for a Collection of Structurally Diverse Inhibitors of Purine Nucleoside Phosphorylase

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