Effect of a New β-Sitosterol Analogue on Plasma Lipid Concentrations in Rats

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概要

• 論文の詳細を見る

• N-Substituted succinamic acid β-sitosteryl ester derivatives were prepared and evaluated. Compounds 1 and 2 were prepared in 76-92% yields by the reaction of β-sitosterol and succinic anhydride, followed by the activation of the resulting acid compound 1 by thionyl chloride or methyl chloroformate, and finally by amination with appropriate amines. Compound 2a (DANA87) was also easily obtained in one step by the direct addition of β-sitosterol to dicyclohexylcarbodiimide (DCC) in 80% yield. Administration of the dietary compound DANA87 resulted in significant decreases in total plasma cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations compared with controls in a rat model. High-density lipoprotein cholesterol and plasma triglyceride levels were not affected. These findings indicate that DANA87 functions as TC and LDL cholesterol-reducing agent.

• 公益社団法人日本薬学会の論文
• 2004-05-01

著者

• Song Yang-heon

  Department Of Chemistry Mokwon University

• Lee Kyunghee

  Department Of Chemistry Mokwon University

• HONG Soonil

  Department of Chemistry, Mokwon University

• LIM Hongsan

  Department of Chemistry, Mokwon University

• SEO Jinmoo

  Department of Chemistry, Mokwon University

• CHUNG Sungjoo

  Department of Chemistry, Mokwon University

• NO Insook

  Department of Chemistry, Mokwon University

• YOON Michung

  Department of Biology, Mokwon University

• No Insook

  Department Of Chemistry Mokwon University

• Yoon Michung

  Department Of Biology Mokwon University

• Hong Soonil

  Department Of Chemistry Mokwon University

• Chung Sungjoo

  Department Of Chemistry Mokwon University

• Seo Jinmoo

  Department Of Chemistry Mokwon University

関連論文

• Effect of a New β-Sitosterol Analogue on Plasma Lipid Concentrations in Rats
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