Synthesis, Anticancer and Antibacterial Activity of Some Novel Mononuclear Ru(II) Complexes

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概要

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• In search of potential anticancer drug candidates in ruthenium complexes, a series of mononuclear ruthenium complexes of the type [Ru(phen)_2(nmit)]Cl_2 (Rul), [Ru(bpy)_2(nmit)]Cl_2 (Ru2), [Ru(phen)_2(icpl)]Cl_2 (Ru3), Ru(bpy)_2(icpl)]Cl_2 (Ru4) (phen=1,10-phenanthroline; bpy=2,2'-bipyridine; nmit=N-methyl-isatin-3-thiosemicarbazone, icpl=isatin-3-(4-Cl-phenyl)thiosemicarbazone) and [Ru(phen)_2(aze)]Cl_2 (Ru5), [Ru(bpy)_2(aze)]Cl_2 (Ru6) (aze=acetazolamide) and [Ru(phen)_2(R-tsc)](ClO_4)_2 (R=methyl (Ru7), ethyl (Ru8), cyclohexyl (Ru9), 4-Cl-phenyl (10), 4-Br-phenyl (Ru11), and 4-EtO-phenyl (Rul2), tsc=thiosemicarbazone) were prepared and characterized by elemental analysis, FTIR, ^1H-NMR and FAB-MS. Effect of these complexes on the growth of a transplantable murine tumor cell line (Ehrlich Ascites Carcinoma) and their antibacterial activity were studied. In cancer study the effect of hematological profile of the tumor hosts have also been studied. In the cancer study, the complexes Ru1-Ru4, Ru10 and Ru11 have remarkably decreased the tumor volume and viable ascitic cell count as indicated by trypan blue dye exclusion test (p<0.05). Treatment with the ruthenium complexes prolonged the lifespan of Ehrlich Ascites Carcinoma (EAC) bearing mice. Tumor inhibition by the ruthenium chelates was followed by improvements in hemoglobin, RBC and WBC values. All the complexes showed antibacterial activity, except Ru5 and Ru6. Thus, the results suggest that these ruthenium complexes have significant antitumor property and antibacterial activity. The results also reflect that the drug does not adversely affect the hematological profiles as compared to that of cisplatin on the host.

• 2004-02-01

著者

• Mazumder U

  Division Of Pharmaceutical Chemist Jadavpur University

• Thangavel Sivakumar

  Division Of Pharmacology Department Of Pharmaceutical Technology Jadavpur University

• Gupta Malaya

  Division Of Pharmacology And Pharmaceutical Chemistry Department Of Pharmaceutical Technology Jadavp

• Gupta Malaya

  Division Of Pharmacology Department Of Pharmaceutical Technology Jadavpur University

• Mazumder Upal

  Division Of Pharmacology And Pharmaceutical Chemistry Department Of Pharmaceutical Technology Jadavp

• Rathinasamy Suresh

  Division Of Pharmaceutical Chemist Jadavpur University

• Bhattacharya Shiladitya

  Division Of Pharmaceutical Chemist Jadavpur University

• Karki Subhas

  Division Of Pharmaceutical Chemist Jadavpur University

• MAZUMDER Upal

  Division of Pharmaceutical Chemist, Jadavpur University

関連論文

• EFFECTS OF METHANOL EXTRACTS OF CAESALPINIA BONDUCELLA AND BAUHINIA RACEMOSA ON HEMATOLOGY AND HEPATORENAL FUNCTION IN MICE
• Antitumor Activity and Antioxidant Status of Caesalpinia bonducella Against Ehrlich Ascites Carcinoma in Swiss Albino Mice
• Synthesis, Anticancer and Antibacterial Activity of Some Novel Mononuclear Ru(II) Complexes

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