Recent Developments in the Maytansinoid Antitumor Agents
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概要
- 論文の詳細を見る
Maytansine and its congeners have been isolated from higher plants, mosses and from an Actinomycete, Actinosynnema pretiosum. Many of these compounds are antitumor agents of extraordinary potency, yet phase II clinical trials with maytansine proved disappointing. The chemistry and biology of maytansinoids has been reviewed repeatedly in the late 1970s and early 1980s; the present review covers new developments in this field during the last two decades. These include the use of maytansinoids as "warheads" in tumor-specific antibodies, preliminary metabolism studies, investigations of their biosynthesis at the biochemical and genetic level, and ecological issues related to the occurrence of such typical microbial metabolites in higher plants.
- 社団法人日本薬学会の論文
- 2004-01-01
著者
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Chan K
College Of Pharmacy The Ohio State University
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CASSADY John
College of Pharmacy, The Ohio State University
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CHAN Kenneth
College of Pharmacy, The Ohio State University
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FLOSS Heinz
Department of Chemistry, Box 351 700, University of Washington
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LEISTNER Eckhard
Institutfur Pharmazeutische Biologic, Rheinische Wilhelms-Universitat
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Floss H
Department Of Chemistry Box 351 700 University Of Washington
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Floss Heinz
Department Of Chemistry Box 351700 University Of Washington
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Cassady John
College Of Pharmacy The Ohio State University
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Chan Kenneth
College Of Pharmacy The Ohio State University
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Leistner E
Institutfur Pharmazeutische Biologic Rheinische Wilhelms-universitat
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Leistner Eckhard
Institut Fur Pharmazeutische Biologie Unversitat Bonn
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