Minor Withanolides from Physalis philadelphica : Structures, Quinone Reductase Induction Activities, and Liquid Chromatography(LC)-MS-MS Investigation as Artifacts

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概要

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• As a result of a bioactivity-guided search for novel, plant-derived cancer chemopreventive agents, ixo-carpalactone A (5) was isolated previously as a potent quinone reductase inducer from the leaves and stems of Physalis philadelphica. In the present study, this promising lead compound was reisolated in gram quantities for in vivo biological testing. During the course of this work, four additional minor new withanolides were also obtained and characterized, namely, 2,3-dihydro-3β-methoxyixocarpalactone A (1), 2,3-dihydro-3β-methoxyixo-carpalactonc B(2), 2,3-dihydroixocarpalactone B(3), and 4β,7β,20R-trihydroxy-1-oxowitha-2,5-dien-22,26-olide (4). However, compounds 1 and 2 were determined using liquid chromatography (LC)-MS-MS to be artifacts generated during the extraction and isolation procedure. Ixocarpalactone A was detected in the fresh fruits (tomatillos) of P.philadelphica by LC-MS-MS analysis at a concentration of 143±4.53 ppb.

• 公益社団法人日本薬学会の論文
• 2003-05-01

著者

• Kinghorn A

  Program For Collaborative Research In The Pharmaciutical Sciences And Department Ofomedicinal Chemis

• Kang Young-hwa

  Program For Collaborative Research In The Pharmaceutical Sciences And Department Of Medicinal Chemis

• Gu Jian-qiao

  Program For Collaborative Research In The Pharmaceutical Sciences And Department Of Medicinal Chemis

• Pezzuto J

  Program For Collaborative Research In The Pharmaciutical Sciences And Deparment Of Medicinal Chemist

• Pezzuto John

  Program For Collaborative Research In Pharmaceutical Sciences And Department Of Medicinal Chemistry

• Li W

  Shenyang Pharmaceutical Univ. Shenyang Chn

• LI Wenkui

  Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemis

• SU Bao-Ning

  Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemis

• FONG Harry

  Program for Collaborative Research in the Pharmaceutical Sciences and Departmant of Medicinal Chemis

• VAN BREEMEN

  Program for Collaborative Research in the Pharmaciutical Sciences and Department of Medicinal Chemis

• KINGHORN A.

  Program for Collaborative Research in the Pharmaciutical Sciences and Department ofoMedicinal Chemis

• Van Breemen

  Program For Collaborative Research In The Pharmaciutical Sciences And Department Of Medicinal Chemis

• Fong Harry

  Program For Collaborative Research In The Pharmaceutical Sciences And Departmant Of Medicinal Chemis

• Su B‐n

  Program For Collaborative Research In The Pharmaceutical Sciences And Department Of Medicinal Chemis

• Kinghorn A.

  Program For Collaborative Reseach In The Pharmaceutical Sciences College Of Pharmacy University Of I

関連論文

• Minor Withanolides from Physalis philadelphica : Structures, Quinone Reductase Induction Activities, and Liquid Chromatography(LC)-MS-MS Investigation as Artifacts
• Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry
• Structure Revision of Polypodoside A. Major Sweet Principle of Polypodium glycyrrhiza

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