Novel Synthesis of Flavonoids of Scutellaria baicalensis GEORGI

概要

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A concise and efficient total synthesis of the flavonoids baicalein, oroxylin A and wogonin was described. Intramolecular oxidative cycli/.ation followed by demethylation of chalcone 1, readily prepared from trimethoxyphenol, afforded, depending upon the controlled conditions, baicalein or oroxylin A in excellent yields. Demethylation of 1 yielded 3, which, by oxidation with I_2/dimethyl sulfoxide (DMSO), was readily converted to oroxylin A and wogonin after column chromatography.
社団法人日本薬学会の論文
2003-03-01