Novel Drug Delivery Device Using Silicone : Controlled Release of Insoluble Drugs or Two Kinds of Water-Soluble Drugs
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概要
- 論文の詳細を見る
Drug release mechanism from silicone carrier differs depending on physicochemical properties of the drug. So far, there have been few reports on controlled release of insoluble drug and on simultaneous release of two kinds of water-soluble drugs. The purposes of this study are to establish methods for (1) continuous release of insoluble drug, and (2) release of two kinds of water-soluble drugs from silicone carrier. Polystyrene beads (PSTB) and proteins such as interferon (IFN) and human serum albumin (HSA) were used as model drugs. PSTB was released from silicone only when citric acid (CA) and sodium bicarbonate (SB) existed as additives. The release patterns of IFN and HSA were almost same in the case of matrix and covered-rod formulations, but double-layered formulation released them in different patterns. As far as we are aware, this is the first report on the release of insoluble drug from silicone and the controlled release of two kinds of water-soluble drugs.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
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Sano A
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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Tanihara M
Nara Inst. Of Sci. And Technol. Nara
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Imanishi Y
The Graduate School Of Materials Science Nara Institute Of Science And Technology
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Imanishi Y
Graduate School Of Materials Science Naist
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KAJIHARA Masako
Research Division, Sumitomo Pharmaceuticals Co., Ltd.
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SUGIE Toshihiko
Research Division, Sumitomo Pharmaceuticals Co., Ltd.
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MAEDA Hiroo
Research Division, Sumitomo Pharmaceuticals Co., Ltd.
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SANO Akihiko
Research Division, Sumitomo Pharmaceuticals Co., Ltd.
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FUJIOKA Keiji
Research Division, Sumitomo Pharmaceuticals Co., Ltd.
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URABE Yosuke
Life Sciences Industry, Dow Corning Asia Ltd.
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TANIHARA Masao
The Graduate School of Materials Science, Nara Institute of Science and Technology
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IMANISHI Yukio
The Graduate School of Materials Science, Nara Institute of Science and Technology
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Sugie Toshihiko
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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Tanihara Masao
The Graduate School Of Materials Science Nara Institute Of Science And Technology
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Maeda Hiroo
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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Urabe Yosuke
Life Sciences Industry Dow Corning Asia Ltd.
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Fujioka K
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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Kajihara Masako
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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