1,5-Dimethyl-6H-pyridazino [4,5-b] carbazole, a 3-Aza Bioisoster of the Antitumor Alkaloid Olivacine

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概要

• 論文の詳細を見る

• A series of b-fused carbazoles structurally related to pyrido[4,3-b]carbazole-type alkaloids was prepared, utilizing the Diels-Alder reaction of 1-methylpyrano[3,4-b]indol-3(9H)-one with electron-deficient acetylenic dienophiles as the key step. The title compound (14) thus obtained in only four steps represents a new 3-aza analog of the antitumor natural product, olivacine.

• 公益社団法人日本薬学会の論文
• 2002-11-01

著者

• Sotelo Eddy

  Lahoratorio De Quimica Farmacciitica Deparhimento De Qitimica Organica Facultud De Farmacia Universi

• HAIDER Norbert

  Institute of Pharmaceutical Chemistry, University of Vienna

• SOTELO Eddy

  Institute of Pharmaceutical Chemistry, University of Vienna

• Haider N

  Institute Of Pharmaceutical Chemistry University Of Vienna

関連論文

• Synthesis of 1-Substituted-6-methyluracils
• Pyridazine Derivatives 32 : Stille-Based Approaches in the Synthesis of 5-Substituted-6-phenyl-3(2H)-pyridazinones
• Pyridazines. Part 31 : Synthesis and Antiplatelet Activity of 4,5-Disubstituted-6-phenyl-3(2H)-pyridazinones
• Pyridazines. XIII. Synthesis of 6-Aryl-5-Oxygenated Substituted-3(2H)-Pyridazinones and Evaluation as Platelet Aggregation Inhibitors
• 1,5-Dimethyl-6H-pyridazino [4,5-b] carbazole, a 3-Aza Bioisoster of the Antitumor Alkaloid Olivacine

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