Microbial Transformation of Rubijervine

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概要

• 論文の詳細を見る

• Preparative-scale fermentation of rubijervine (1), the known 22,26-epiminocholestane Veratrum alkaloid, with Cunningharnella echinulata ATCC 9244 has resulted in the isolation of the new metabolites 7α-hydroxyrubi-jervine (2) and solanid-5-ene-3β,12α-diol-1-one (3). Structure elucidation of these metabolites was based primarily on iD- and 2D-NMR analyses. The microbe C. echinulata ATCC 9244 was able to metabolize rings A and B of rubijervine but failed to metabolize rings C, D or its N-containing side chain, a finding which is analogous to the results of previous fermentation studies of steroidal alkaloids.

• 公益社団法人日本薬学会の論文
• 2002-11-01

著者

• Dunbar D.

  National Center For Natural Products Research University Of Mississippi

• EL SAYED

  Pharmacognosy Department, Faculty of Pharmacy, Mansoura University

• El Sayed

  Pharmacognosy Department Faculty Of Pharmacy Mansoura University

• Sayed Khalid

  Pharmacognosy Department, Faculty of Pharmacy, Mansoura University

• Dumbar D.

  National Center for Natural Products Research, University of Mississippi

関連論文

• Microbial Transformation of Rubijervine

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