環境調和型合成反応を指向した水中ラジカル反応の開発
スポンサーリンク
概要
- 論文の詳細を見る
The aqueous medium radical reactions of a variety of imine derivatives such as oxime ether, oxime, hydrazone, nitrone, and N-sulfonylimine were investigated. Triethylborane-mediated intermolecular alkyl radical addition to glyoxylic oxime ether, oxime, and nitrone in water proceeded smoothly to give α-amino acid derivatives in good yields. Alkyl radical addition to N-sulfonylimine proceeded in aqueous media using zinc as a radical initiator. The zinc-mediated radical reaction of the hydrazone with a chiral camphorsultam provided the corresponding alkylated products with good diastereoselectivities, which could be converted into enantiomerically pure α-amino acids. The indium-mediated radical reactions provide new opportunities for carbon-carbon bond formation such as alkylation reactions of imines and 1,4-addition to electron-deficient olefins. The indium-mediated tandem reactions also proceeded effectively via two carbon-carbon bond-forming processes for the preparation of various types of functionalized cyclic compounds.
- 2004-06-01
著者
関連論文
- 新規ラジカル的アジド化反応
- 環境調和型合成反応を指向した水中ラジカル反応の開発
- 101(P-18) ラジカル反応を用いたアミノ酸類の新規不斉合成法の開発(ポスター発表の部)
- NMRで反応混合液中の不安定反応中間体を見る(1) : DOSY (Diffusion Ordered Spectroscopy) による反応混合物中の不安定反応中間体の構造解析
- 共役オキシムエーテル類へのラジカル付加反応を基盤としたドミノ型反応の開発