Mammalian Phospholipase A_2 : Phospholipase A_2 Receptor(Diversity of Phospholipase A_2 Enzymes)

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概要

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• The phospholipase A_2 receptor (PLA_2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA_2R regulates a variety of biological responses elicited by secretory phospholipase A_2s (sPLA_2s). Group IB sPLA_2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production. Analysis of PLA_2R-deficient mice suggested a potential role of the sPLA_2-IB/PLA_2R pathway in the production of proinflammatory cytokines during endotoxic shock. PLA_2R is also involved in the clearance of sPLA_2s, especially group X sPLA_2, to protect their exaggerated reactions by potent enzymatic activities. In circulation, the soluble form of PLA_2R is constitutively present as an endogenous inhibitor for mammalian sPLA_2s.

• 公益社団法人日本薬学会の論文
• 2004-08-01

著者

• Hanasaki Kohji

  Shionogi & Co. Ltd.

• Hanasaki Kohji

  Shionogi Research Laboratories Shionogi & Co. Ltd.

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