Feitai Attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats (Pharmacology)

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概要

• 論文の詳細を見る

• Pulmonary fibrosis is a common consequence of numerous pulmonary diseases. The current therapeutic approaches for this condition are unsatisfactory. Feitai, a composite formula consisting of several herbs, is used in China as a folk remedy for treating patients with pulmonary tuberculosis. In this study, we extensively investigate the effects and mechanisms of Feitai on bleomycin (BLM)-induced pulmonary fibrosis in rats. One hundred and twenty male Sprague-Dawley rats were randomly divided into four groups, referred to as the saline-water, saline-Feitai, BLM-water, and BLM-Feitai groups. Following a single instillation of BLM (5 mg/kg) or saline, rats were orally administered Feitai at a dose of 3 g/kg body weight or sterilized distilled water once daily. Rats were killed at 7, 14, or 28 d post-BLM. Inflammatory cell count, protein concentration, and lactate dehydrogenase activity in bronchoalveolar lavage fluid were measured, and myeloperoxidase activity and lipid peroxide content in lung homogenates were analyzed. Treatment with Feitai inhibited lung fibrotic progression induced by BLM, as indicated by the decrease in lung hydroproline content and lung fibrosis score at 28 d post-BLM. This was accompanied by significant amelioration of BLM-induced body weight loss, lung edema, and inflammatory response during the development of lung injury in the acute phase. The results strongly indicate the beneficial effects of Feitai in protecting against BLM-induced pulmonary fibrosis. Furthermore, the inflammatory response and lipid peroxidation were inhibited by Feitai, suggesting that the effect of this formula on BLM-induced lung injury and fibrosis is associated with antiinflammatory and antioxidant properties.

• 公益社団法人日本薬学会の論文
• 2004-05-01

著者

• Liu Yong-zhen

  中華人民共和国

• Liu Yong-zhen

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Huang Cheng-gang

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Gong Li-kun

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Wang Hui

  中華人民共和国

• Chen Fang-ping

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Cai Yan

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• LI Xiang-Hong

  State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for

• WANG Hui

  State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for

• ZHANG Ling

  Shanghai Pulmonary Hospital

• QI Xin-Ming

  State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for

• LIU Lin-Lin

  State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for

• WU Xiong-Fei

  State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for

• REN Jin

  State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for

• Wang Hui

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Li Xiang-hong

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Wu Xiong-fei

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Qi Xin-ming

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Ren Jin

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

• Liu Lin-lin

  State Key Laboratory Of Drug Research Shanghai Institute Of Materia Medica Shanghai Institutes For B

関連論文

• Feitai Attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats (Pharmacology)
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