2'-O, 4'-C-Ethylene-Bridged Nucleic Acids (ENA^<TM>) as Next-Generation Antisense and Antigene Agents (Biological and Pharmaceutical Aspects of Nucleic Acids Chemistry)

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概要

• 論文の詳細を見る

• Novel 2'-O, 4'-C-ethylene nucleosides have been synthesized as building blocks for antisense and antigene oligonucleotides. 2'-O, 4'-C-Ethylene-bridged nucleic acids (ENA^<TM>) comprising 2'-O, 4'-C-ethylene nucleosides have considerable affinity to complementary RNA and double-stranded DNA. Incorporation of 2'-O, 4'-C-ethylene nucleosides into oligonucleotides dramatically increase their resistance against exonucleases. In this review, the properties of ENA oligonucleotides and some of their applications as antisense and antigene oligonucleotides are described.

• 公益社団法人日本薬学会の論文
• 2004-04-01

著者

• Koizumi Makoto

  Lead Discovery Research Laboratories Sankyo Co. Ltd.

関連論文

• 2'-O, 4'-C-Ethylene-Bridged Nucleic Acids (ENA^) as Next-Generation Antisense and Antigene Agents (Biological and Pharmaceutical Aspects of Nucleic Acids Chemistry)

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