Fucoidan Modulates the Effect of Transforming Growth Factor (TGF)-β_1 on Fibroblast Proliferation and Wound Repopulation in in Vitro Models of Dermal Wound Repair(Biopharmacy)

概要

論文の詳細を見る
Aberrant wound healing, either causing scarring or chronic wounds, is a significant cause of morbidity. There is therefore, considerable interest in agents which can modulate certain aspects of the wound healing process. Fucoidans, sulphated polyfucose polysaccharides which may be extracted from Fucus spp., have been shown to modulate the effects of a variety of growth factors through mechanisms thought to be similar to the action of heparin. We investigated the interaction between two commercial preparations of fucoidan and transforming growth factor (TGF)-β_1. These preparations of fucoidan, as well as heparin, inhibited fibroblast proliferation at concentrations from 0.01 to 100mg/ml. The anti-proliferative effects of 1 ng/ml TGF-/J, on dermal fibroblasts were abrogated by fucoidan preparation F7 when used at concentrations over 1 mg/ml. In a three dimensional in vitro model of wound repair, the fibroblast populated collagen lattice or "dermal equivalent", TGF-β_1, reduced the rate of fibroblast repopulation of a wound defect created by punch biopsy. Addition of fucoidan to the model in the presence of TGF-β_1 increased the rate of fibroblast repopulation of the wound and at 10 mg/ml of fucoidan the number of cells which had migrated into the wounded defect was similar to that of control cultures. These data suggest that fucoidan has properties which may be beneficial in the treatment of wound healing.
公益社団法人日本薬学会の論文
2004-02-01

Fucoidan Modulates the Effect of Transforming Growth Factor (TGF)-β_1 on Fibroblast Proliferation and Wound Repopulation in in Vitro Models of Dermal Wound Repair(Biopharmacy)

スポンサーリンク

概要

著者

関連論文

スポンサーリンク