Curcumin Ameliorates Left Ventricular Function in Rabbits with Pressure Overload : Inhibition of the Remodeling of the Left Ventricular Collagen Network Associated with Suppression of Myocardial Tumor Necrosis Factor-α and Matrix Metalloproteinase-2 Expre

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概要

• 論文の詳細を見る

• Objective: Curcumin is a wide-spectrum cellular protector with antiinflammatory, antioxidizant, and antiflbrotic effects. This study was conducted to investigate its effects on myocardial collagen remodeling in pressure overloaded rabbits. Methods and Results: Pressure overloaded rabbits were established by partial abdominal aorta ligation. The rabbits were divided into the sham-operation group, vehicle group and curcumin group. Curcumin was administered orally at a dose of 100mg/kg・d in 10ml of 2.5% polyethylene glycol solution and the other 2 groups were given the same dose of polyethylene glycol solution. Compared with the vehicle group, left ventricular function in the curcumin group was significantly ameliorated, as indicated by decreased left ventricular end-diastolic pressure, left ventricle weight to body weight ratio, and the left ventricular posterior wall thickness. The collagen volume fraction in the curcumin group was also reduced. Myocardial tumor necrosis factor (TNF)-α and matrix metalloproteinase (MMP)-2 expression were significantly overexpressed in the vehicle group and markedly suppressed in the curcumin group at both the 4th and 8th weeks. At the end of the 8th week, the ejection fraction in the curcumin group was increased compared with that in the vehicle group. Conclusion: Curcumin improved left ventricular function in pressure overloaded rabbits. This might be duo to inhibition of collagen remodeling associated with suppression of myocardial expression of tumor necrosis factor-α, and matrix metalloproteinase-2.

• 公益社団法人日本薬学会の論文
• 2004-02-01

著者

• Chen Shao-bo

  Department Of Cardiology The First Hospital Of Medical School Of Xi'an Jiaotong University

• Lian Jiang-fang

  Department Of Cardiology The First Hospital Of Medical School Of Xi'an Jiaotong University

• Wang Jun-kui

  Department Of Cardiology The First Hospital Of Medical School Of Xi'an Jiaotong University

• Yao Qing-hai

  Department Of Cardiology The First Hospital Of Medical School Of Xi'an Jiaotong University

• Wang Dong-qi

  Department Of Cardiology The First Hospital Of Medical School Of Xi'an Jiaotong University

• Yuan Zu-yi

  Department Of Cardiology The First Hospital Of Medical School Of Xi'an Jiaotong University

• Yao Xiao-wei

  Department Of Cardiology The First Hospital Of Medical School Of Xi'an Jiaotong University

• CUI Chang-Cong

  Department of Cardiology, The First Hospital of Medical School of Xi'an Jiaotong University

• Cui Chang-cong

  Department Of Cardiology The First Hospital Of Medical School Of Xi'an Jiaotong University

関連論文

• Curcumin Ameliorates Left Ventricular Function in Rabbits with Pressure Overload : Inhibition of the Remodeling of the Left Ventricular Collagen Network Associated with Suppression of Myocardial Tumor Necrosis Factor-α and Matrix Metalloproteinase-2 Expre
• Curcumin Ameliorates Left Ventricular Function in Rabbits with Pressure Overload : Inhibition of the Remodeling of the Left Ventricular Collagen Network Associated with Suppression of Myocardial Tumor Necrosis Factor-α and Matrix Metalloproteinase-2 Expre

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