Comparative Evaluation of in-Vitro Effects of Brazilian Green Propolis and Baccharis dracunculifolia Extracts on Cariogenic Factors of Streptococcus mutans(Miscellaneous)
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概要
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Streptococcus mutans triggers dental caries establishment by two major factors: synthesis of organic acids, which demineralize dental enamel, and synthesis of glucans, which mediate the attachment of bacteria to the tooth surface. Propolis is a natural product that may prevent dental caries. Baccharis dracunculifolia DC (Asteraceae), a native plant from Brazil, is the most important botanical origin for the production of green propolis (Brazilian propolis) by honeybees. However, whether B. dracunculifolia (Bd) has an anticariogenic effect, like green propolis, remains unknown. Herein, we have made a comparative evaluation of the effects of extracts from green propolis and Bd on the glucan synthesis and acidogenic potential of S. mutans. The inhibitory effects of the extracts on bacterial acid production were evaluated through the potentiometric measurement of pH from bacterial suspensions treated with serial concentrations of both extracts. Besides presenting close inhibitory values at the same concentration range, Bd leaf rinse and green propolis extracts had similar IC_<50> values (0.41 and 0.34 mg/ml, respectively). Both extracts produced a bacteriostatic effect on S. mutans cultures at a concentration of 0.40 mg/ml. Estimated inhibitory values of green propolis and Bd leaf rinse extracts on the synthesis of insoluble glucans (IC_<50>=12.9 and 25.0 μg/ml, respectively) and soluble glucans (IC_<50>=50.4 and 49.1 μg/ml, respectively) were not significantly different from each other at p<0.05. The results demonstrate that Bd leaf rinse and green propolis extracts have similar inhibitory effects on the S. mutans cariogenic factors evaluated herein, and allowed us to suggest that Bd leaves may be a potential source for pharmaceutical products employed for this purpose.
- 公益社団法人日本薬学会の論文
- 2004-11-01
著者
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Da Silva
Laboratorio De Desenvolvimento Galenico Faculdade De Farmacia Universidade Federal Do Rio Grande Do
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Leitao Denise
Laboratorio De Bioquimica Faculdade De Ciencias Farmaceuticas De Ribeirdo Preto-universidade De Sao
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BASTOS Jairo
Laboratorio de Farmacognosia, Departamento de Ciencias Farmaceuticas, USP
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POLIZELLO Ana
Laboratorio de Bioquimica, Faculdade de Ciencias Farmaceuticas de Ribeirdo Preto-Universidade de Sao
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SPADARO Augusto
Laboratorio de Farmacognosia, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto-Universidade de
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Bastos Jairo
Laboratorio De Bioquimica Faculdade De Ciencias Farmaceuticas De Ribeirdo Preto-universidade De Sao
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Polizello Ana
Laboratorio De Bioquimica Faculdade De Ciencias Farmaceuticas De Ribeirdo Preto-universidade De Sao
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Da Silva
Laboratorio De Farmacognosia Faculdade De Ciencias Farmaceuticas De Ribeirao Preto-universidade De S
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Spadaro Augusto
Laboratorio De Farmacognosia Faculdade De Ciencias Farmaceuticas De Ribeirao Preto-universidade De S
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Da Silva
Laboratorio De Biologia Celular E Tecidual
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