Effects of Omeprazole, Famotidine, and Ranitidine on the Enzyme Activities of Carbonic Anhydrase from Bovine Stomach in Vitro and Rat Erythrocytes in Vivo(Biochemistry/Molecular Biology)

スポンサーリンク

概要

• 論文の詳細を見る

• In this study, the effects of omeprazole, famotidine, and ranitidine on bovine stomach carbonic anhydrase (EC 4.2.1.1.) isoenzymes have been investigated in vitro. Bovine stomach carbonic anhydrase (CA) was purified from four different cell localisations of bovine stomach using affinity chromatography by Sepharose 4B-L-tyrosine sulphanilamide. The inhibition or activation effects of three different medical drugs on CA isoenzymes were determined using esterase activity and the CO_2-hydratase method by plotting activity % vs. [medical drug]. The K_i values for omeprazole, famotidine, and ranitidine were determined in all localization CA, respectively. The I_<50> values of the drugs exhibiting an inhibition effect were found by means of these graphs. It was observed that omeprazole, famotidine, and ranitidine showed inhibition of bovine stomach CA activity. In addition, in vivo studies were performed for these medical drugs in Sprague-Dawley rats. It was demonstrated that CA in erythrocytes was significantly inhibited by these drugs to 3 h.

• 公益社団法人日本薬学会の論文
• 2004-11-01

著者

• Demir Nazan

  Department Of Chemistry Faculty Of Science Ataturk University

• Demir Yasar

  Department Of Chemistry Faculty Of Education Ataturk University

• NADAROGLU Hayrunnisa

  Department of Food Technology, Oltu Technical School, Ataturk University

• Nadaroglu Hayrunnisa

  Department Of Food Technology Oltu Technical School Ataturk University

関連論文

• Effects of Omeprazole, Famotidine, and Ranitidine on the Enzyme Activities of Carbonic Anhydrase from Bovine Stomach in Vitro and Rat Erythrocytes in Vivo(Biochemistry/Molecular Biology)

スポンサーリンク