Trypsinogen hL is not a New Member of the Human Trypsinogen Family, but a Known Mouse Ortholog(Communications to the Editor)

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概要

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• An allegedly novel human trypsinogen cDNA clone termed trypsinogen hL was recently reported in the Biological & Pharmaceutical Bulletin (2003; 26: 361-364). This "new" trypsinogen sequence was isolated by PCR using human lung cDNAs as template and was presumed to be a new member of the human trypsinogen family. However, trypsinogen hL does not match any sequence in the human genome; whereas it is 100% identical to mouse trypsinogen 7. Thus, trypsinogen hL is not of human origin, and its cloning from a human CDNA library was clearly a result of contamination with mouse genetic material. Publication of this cloning artifact could have been avoided by a simple BLAST search of GenBank or other sequence data-banks.

• 2003-06-01

著者

• Chen Jian-min

  Inserm-emi O115 Genetique Moleculaire Et Genetique Epidemiologique Universite De Bretagne Occidental

• Sahin-toth Miklos

  Department Of Molecular And Cell Biology Boston University Goldman School Of Dental Medicine

• FEREC Claude

  INSERM-EMI O115, Genetique Moleculaire et Genetique Epidemiologique, Universite de Bretagne Occidentale, Etablissement Francois du Sang-Bretagne, Centre Hospitaller Universitaire

• Ferec Claude

  Inserm-emi O115 Genetique Moleculaire Et Genetique Epidemiologique Universite De Bretagne Occidentale Etablissement Francois Du Sang-bretagne Centre Hospitaller Universitaire

関連論文

• Trypsinogen hL is not a New Member of the Human Trypsinogen Family, but a Known Mouse Ortholog(Communications to the Editor)

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