Antioxidant Evaluations of Novel N-H and N-Substituted Indole Esters

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概要

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• The anti-lipid peroxidation (LP) activity and anti-superoxide formation (SOD) of new N-H and N-substituted in dole derivatives were evaluated to determine their antioxidant activity. The results showed that compounds 1, 2, 5, 9 and 12 demonstrate considerable inhibition of lipid peroxidation of mouse liver homogenate. On the other hand, compounds 5 and 12 showed anti-superoxide formation activity at a concentration of 10^<-4>_M. Consequently, it can be concluded that these compounds exhibit important activity compared with reference compound α-tocopherol (vitamin E).

• 公益社団法人日本薬学会の論文
• 2003-05-01

著者

• Coban T

  Ankara Univ. Ankara Tur

• Coban Tulay

  Department Of Toxicology Faculty Of Pharmacy Ankara University

• Oelgen Suereyya

  トルコ

• OLGEN Sureyya

  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara

関連論文

• Evaluation of the Antioxidant Effects of Some Flavonylthiazolidinediones by Determining Their Effects on Lipid Peroxidation, Superoxide Anion Formation, and 2,2-Diphenyl-1-picrylhydrazyl Stable Free Radical(Medicinal Chemistry)
• Antioxidant Evaluations of Novel N-H and N-Substituted Indole Esters

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