Radioprotective Effect of Panax ginseng on the Phosphatases and Lipid Peroxidation Level in Testes of Swiss Albino Mice
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概要
- 論文の詳細を見る
The Panax ginseng has been used as traditional medicine for past several years among oriental people. The present investigation has been made to assess the radioprotective efficacy of ginseng root extract in the testicular enzymes of Swiss albino mice. The Swiss albino mice were divided into different groups, (I) Ginseng treated group : The animals were administered lOmg/kg body weight ginseng root extract I. P. (ii) Radiation treated group : The animals were exposed to 8Gy gamma radiation at the dose rate of 1. 69Gy/min at the distance of 80cm. (iii) Combination group : Animals were administered ginseng extract continuously for 4d and on 4th day they were irradiated to 8Gy gamma radiation after 30 min of extract administration. The animals from above groups were autopsied on day 1, 3, 7, 14 and 30. Biochemical estimations of acid and alkaline phosphatases and Lipid peroxidation (LPO) in testes were done. In ginseng treated group acid and alkaline phosphatases activity and LPO level did not show any significant alteration. In irradiated animals there was a significant increase in acid phosphatase activity and LPO level. However, significant decline in alkaline phosphatase activity was observed. The treatment of ginseng before irradiation causes significant decrease in acid phosphatase and LPO level and significant increase in alkaline phosphatase activity. One of the cause of radiation damage is lipid peroxidation. Due to lipid peroxidation, lysosomal membrane permeability alters and thus results in release of hydrolytic enzymes. So, an increase in acid phosphatase was noticed after radiation treatment. The alkaline phosphatase activity is associated with membrane permeability and different stages of spermatogenesis. Due to membrane damage and depletion of germ cells of testes after irradiation the enzyme activity was decreased. Ginseng markedly inhibits lipid peroxidation. It acts in indirect fashion to protect radical processes by inhibition of initiation of free radical processes and thus reduces the radiation damages in testes of Swiss albino mice.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
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Kumar Ashok
Department Of Agronomy Ccs Haryana Agricultural University
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Kumar Ashok
Department Of Zoology University Of Rajasthan
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Kumar Madhu
Department Of Zoology University Of Rajasthan
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Kumar Ashok
Cell and Molecular Biology Laboratory, Department of Zoology, University of Rajasthan
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SHARMA Mukesh
Department of Zoology, University of Rajasthan
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SAXENA Preeti
Department of Zoology, University of Rajasthan
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Saxena Preeti
Department Of Zoology University Of Rajasthan
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