Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis(Medicinal Chemistry)

概要

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A marine sponge Petrosia similis afforded two compounds which belongs to bis-quinolizidine alkaloids namely, petrosin (1) and petrosin-A (2), respectively. Petrosin (1) and petrosin-A (2) showed anti-HIV inhibition with IC_<50> values of 41.3 and 52.9 μm respectively. MAGI cell assays indicated that the compounds inhibited early steps of HIV replication. In extracellular HIV-1 Reverse Transcriptase inhibition assay petrosin and petrosin-A inhibited HIV-1 RT at 10.6 and 14.8μm. This is the first report of petroisns with anti-HIV activity.
公益社団法人日本薬学会の論文
2003-10-01