デキストラン硫酸を使った吸着材の原理と性能

概要

論文の詳細を見る
The structure, the adsorption mechanism, and the clinical performance of two adsorbents with dextransulfate ligand, Liposorber^<TM> for LDL apheresis and Selesorb^<TM> for the removal of autoantibodies in SLE patients, are reviewed and discussed. In both adsorbents, the polyanionic nature of dextransulfate plays the key role in recognizing and binding LDL or autoantibodies such as anti-LDA antibody and anti-cardiolipin antibody. The polycationic moiety of apoB protein on the LDL surface is the counterpart of the binding with dextransulfate. The similarity of the electric structure between dextransulfate and antigens for autoantibodies, i.e., DNA and cardiolipin, for example, induces the binding. The electric nature of the adsorption is confirmed by the adsorbed LDL or autoantibodies being desorbed by increasing ionic strength. This phenomenon is applied in the continuous adsorption system by using 2 columns that alternatively repeat the adsorption and desorption steps. Liposorber^<TM> and Selesorb^<TM> both have been clinically used for more than 10 years, and their clinical effectiveness and safety are well established. The recent results of the clinical studies are also reviewed.
日本アフェレシス学会の論文
2000-06-30