血漿吸着材イムソーバPH,TR,プラソーバBRの原理と性能

概要

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Principles and performances of plasma adsorbent, Immusorba PH, TR and Plasorba BR are described. The adsorbent PH and TR are porous, hydrophilic polyvinyl alcohol gel immobilized phenylalanine and tryptophan, respetively. The PH adsorbent, which is applied to patients with rheumatoid arthritis and SLE, can adsorb the rheumatoid factor, immune complex and anti-DNA antibodies. The TR adsorbent can remove antiacetylcholin receptor (AChR) antibodies, which are the pathogenic substance of myasthenia gravis. It can also absorb TNF-alpha, which plays an important role in the immune system. The adsorption mechanism of these pathogenic substances are hydrophobic and ionic interaction. The BR adsorbent is porous styrenedivinylbenzene copolymer with quarterly ammonium base as ligand. It can adsorb bilirubin and bilic acids by ionic interaction and is applied to hepatic failure.
日本アフェレシス学会の論文
2000-06-30