骨シンチグラムのノーマライズ化

概要

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The discovery of bone-seeking compounds that can be labeled with technetium-99m has increased the clinical application of bone scanning. However, if studies of same patient are done at different time, qualitative representations of tracer distribution can suggest changes unrelated to the patient's condition. These difference may be due to scanning conditions that involve injection dose, waiting time, scan speed, and photo factors (cut off, window width, deviation...). Therefore, if the same set of scanning conditions for a particular patient is always used, serial studies should be comparable. We named these serial scintigrams, that can be comparable, "Normalized Scintigrams." But one can guess that this method is a very inconvenient, particulally it is almost impossible setting same injection dose, waiting time, in a series of studies. So our "Normalized Method" does't fix these two scanning conditions (injection dose, and waiting time), and difference of these from first scanning are supplied by scanning speed. Other scanning conditions, they are "photo factors" are fixed the most suitable condition with bone image, and this is not inconvenient. By this method, Normalized Bone Scanning can be performed easily, and changes in disease condition can be evaluated since disease activity is expressed in terms of density on the scintigrams.
1979-05-01