温度およびpHがproton-MRSで測定される代謝物質の周波数に与える影響

概要

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The chemical shift of water in proton-MRS is dependent on the sample temperature. Thus the target temperature can be calculated by measuring changes in the frequency difference between water and metabolites. There have been some clinical reports on measuring brain temperature using this method. However, various questions arise as to whether this method can be applied in a severely damaged brain(head injury, cerebrovascular disease)where in-vivo pH has shifted far from normal. We here report the results of our basic experiments using phantoms to clarify whether pH as well as temperature of the target may change the frequency difference between water and metabolites. Our data showed that the frequency difference between water and metabolites (choline, creatine, NAA)changed by 0.01 ppm as phantom temperature declined 1℃ (32-40℃),but was not affected by changes in phantom pH (3.2-9.6). Since the chemical shift of metabolites was shown to be independent of target pH, it is feasible to measure in-vivo brain temperature less invasively using proton-MRS even in patients with severe brain damage.
公益社団法人日本放射線技術学会の論文
2001-06-20