Isolation of a Fibronectin-like Molecule from a Marine Bivalve, Pinctada fucata, and Its Secretion by Amebocytes(Cell Biology)

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概要

• 論文の詳細を見る

• A gelatin-binding protein (GBP) was isolated from the hemolymph of the pearl oyster, Pinctada fucata, by affinity chromatography using gelatin-Sepharose. The purified product was a monomer of 220 kDa that showed weak cell spreading activity toward baby hamster kidney cells. GBP was also detected in connective tissues in an insoluble form polymerized by disulfide bonds. Thus, GBP seems to be a fibronectin-like molecule, sharing some properties with vertebrate fibronectin except for the subunit structure of the soluble form. Amebocytes secreted GBP as a component of the extracellular matrix (ECM) in vitro, and in vivo GBP was deposited together with type I-like collagen in the amebocyte sheath formed at wound sites. It is known that amebocytes of the pearl oyster synthesize an ECM containing collagen and proteoglycans upon which epithelial cells migrate at wound sites. Therefore, GBP may play a role in the healing process as a cell-adhesion molecule.

• 社団法人日本動物学会の論文
• 1992-06-15

著者

• Suzuki Tohru

  Nutrition Division National Research Institute Of Aquaculture

• FUNAKOSHI SHOJI

  Nutrition Division, National Research Institute of Aquaculture

関連論文

• Immunolocalization and in vitro Secretion of Hemolymph Lectin of the Pearl Oyster, Pinctada fucata martensii(Cell Biology)
• Isolation of a Fibronectin-like Molecule from a Marine Bivalve, Pinctada fucata, and Its Secretion by Amebocytes(Cell Biology)

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