Estrogen Stimulates Peptidylarginine Deiminase Biosynthesis in the Primary Culture of Dispersed Rat Anterior Pituitary Cells(Endocrinology)
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概要
- 論文の詳細を見る
Effects of sex steroids on peptidylarginine deiminase biosynthesis were examined in the primary culture of dispersed rat anterior pituitary cells. Without steroids, cells from 7 week to 6 month-old rats incorporated [^<35>S]-amino acids into the immunoprecipitable enzyme protein. No incorporation was detected in cells from 4 week-old rats. The cells responded to 10 nM 17μ-estradiol (E_2) by an increase in the rate of enzyme biosynthesis regardless of sex and age of the rats. Diethylstilbestrol was as effective as E_2, whereas testosterone and progesterone had no effect. Dot blot hybridization analysis demonstrated an increase in the znzyme mRNA level in the E_2-stimulated cells. The results support that estrogen up-regulates the peptidylarginine deiminase expression in the rat pituitary.
- 1991-08-15
著者
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SENSHU Tatsuo
Department of Bioactivity Regulation, Tokyo Metropolitan Institute of Gerontology
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Nagata Saburo
Department Of Applied Physics Faculty Of Engineering Kobe University
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Nagata Saburo
Department Of Biochemistry Tokyo Metropolitan Institute Of Gerontology
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Senshu Tatsuo
Department Of Biochemistry Tokyo Metropolitan Institute Of Gerontology
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Senshu Tatsuo
Department Of Bioactivity Regulation Tokyo Metropolitan Institute Of Gerontology
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