Morphological and Functional Organization of ON and OFF Pathways in the Adult Newt Retina(Neurobiology)

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概要

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• Morphological and functional organization of ON and OFF pathways in the adult newt retina were examined by intracellular recording and staining techniques and immunohistochemistry. Synaptotagmin immunoreactivity discriminated three broad bands within the IPL : the distal band (sublamina I), the middle band (sublamina II) consisting of two dense punctate bands (sublaminae II_a and II_b), and proximal band (sublamina III). The Lucifer-yellow labeled OFF amacrine and ganglion cells send their processes mainly in sublamina I and/or II_a where OFF bipolar cells extend their axon terminals, while ON amacrine and ganglion cells send their processes in sublamina III and/or lib where ON bipolar cells extend their axon terminals. Processes of ON-OFF amacrine and ganglion cells ramify broadly in the whole thickness of the IPL. Many bipolar cells responded to light spot with a transient hyperpolarization at both light onset and offset. They are probably subtypes of ON bipolar cells, because their axon terminals branch mainly in sublaminae III and/or II_b, although a few cells ramified the axon at both sublaminae II_a and III. Two immunohistochemical markers for bipolar cells, PKC and RB-1, identified axon terminals in sublaminae III and/or II_b From the ramification pattern of axon terminal, they are probably subtypes of ON bipolar cells. ChATir amacrine cells ramified their dendrites in either sublamina I or ll_b. Altogether, present studies support the general idea of segregation of ON and OFF pathways in sublaminae a and b of the IPL.

• 社団法人日本動物学会の論文
• 2003-03-25

著者

• SAITO Takehiko

  Institute of Biological Sciences, University of Tsukuba

• Saito Takehiko

  Institute Of Biological Sciences University Of Tsukuba

• UMINO Yumiko

  Institute of Biological Sciences, University of Tsukuba

• Umino Yumiko

  Institute Of Biological Sciences University Of Tsukuba

• Niino Miyuki

  Eisai Co. Ltd.

• Saito Takehiko

  Institute Of Biological Sciences Institute Of Biological Sciences University Of Tsukuba

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• Structure and Action of Bioactive Peptides Isolated from the Newt, Cynops pyrrhogaster : II. Four VIP-Related Peptides and Two Neurotensin-Related Peptides
• Morphological and Functional Organization of ON and OFF Pathways in the Adult Newt Retina(Neurobiology)
• GABA_A-receptor-mediated increase in intracellular Ca^ concentration in the regenerating retina of adult newt
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