Erythropoiesis and Conversion of RBCs and Hemoglobins from Larval to Adult Type during Amphibian Development
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概要
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In anuran amphibians transitions of hemoglobins (Hbs) and red blood cells (RBCs) from the larval to the adult type have been reported to occur at metamorphosis, depending on certain influence of thyroid hormones (THs). Contrary to this, transition of RBCs/Hbs from the larval to the adult type during the metamorphosis in a urodele, Hynobius retardatus occurs almost independently of thyroid activity, but dependent on certain pituitary factor(s). All findings reported so far support the idea that the Hb switching in H. retardatus occurs in a single RBC population ("Hb switching" model), rather than the concept that larval RBCs are replaced by new, adult RBCs ("RBC replacement" model) as is known to occur in many anurans. Erythropoiesis in vertebrates occurs with two distinct phases, termed primitive and definitive. Primitive erythropoiesis generally provides embryonic/larval erythroids, and definitive hematopoiesis contributes to adult RBCs. Primitive erythropoiesis in Xenopus laevis occurs in the ventral blood island (VBI), and the dorsolateral plate (DLP) cells remain undifferentiated until later for definitive hematopoiesis. H. retardatus embryos also have two distinct hematopoietic sites, the VBI and DLP. The DLP cells of H. retardatus, however, differentiate in situ to RBCs containing larval globin, suggesting that both the VBI and DLP contribute to "primitive" erythropoiesis. Some DLP cells may be set aside in an undifferentiated state during embryogenesis for future "definitive" erythropoiesis coming to express only adult globin during metamorphosis. A tentative model was proposed to explain similarities and dissimilarities in erythropoiesis and conversion of RBCs/Hbs between anurans and urodeles.
- 2001-09-20
著者
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Wakahara Masami
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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Wakahara Masami
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Yamaguchi Masahiro
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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Yamaguchi Masahiro
Division Of Biological Sciences Graduate School Of Science Hokkaido University:(present Address)daii
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Yamaguchi Masahiro
Division Of Biological Sciences Graduate School Of Science Hokkaido University
関連論文
- DIFFERENTIATED REACTION NORMS UNDER DIFFERENT SELECTIONS IN POLYMORPHISM: BROAD-HEADED MORPH IN HYNOBIUS RETARDATUS(Behavior Biology and Ecology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Erythropoiesis and Conversion of RBCs and Hemoglobins from Larval to Adult Type during Amphibian Development
- TEMPERATURE-DEPENDENT SEX DIFFERENTIATION IN HYNOBIUS RETARDATUS : EXPRESSION PATTERN OF P450-AROMATASE(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- PHYLOGEOGRAPHY OF THE SALAMANDER HYNOBIUS RETARDATUS BASED ON PARTIAL mtDNA SEQUENCE(Behavior Biology and Ecology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Several Biochemical Alterations from Larval to Adult Types are Independent on Morphological Metamorphosis in a Salamander, Hynobius retardatus
- DEVELOPMENT OF PRIMORDIAL GERM CELLS (PGCS) IN THE JAPANESE NEWT CYNOPS PYRRHOGASTER(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- EXPRESSION ANALYSIS OF A GENE EXPRESSED IN THE GERM LINE IN URODELE EMBRYOS(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Adaptable Larval Life Histories in Different Populations of the Salamander, Hynobius retardatus, Living in Various Habitats(Animal Diversity and Evolution)
- Variation in Cannibalistic Polyphenism between Populations in the Salamander Hynobius retardatus(Ecology)
- Heterochronic Expression of Several Adult Phenotypes in Normally Metamorphosing and Metamorphosis-Arrested Larvae of a Salamander Hynobius retardatus
- Heterochrony and Neotenic Salamanders : Possible Clues for Understanding the Animal Development and Evolution
- HETEROCHRONIC EXPRESSION OF SEVERAL ADULT PHENOTYPES DURING METAMORPHOSIS OF A SALAMANDER HYNOBLUS RETARDATUS