Adenylate Cyclase Mediates Olfactory Transduction of Amino Acid Responses in the Newt

概要

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It has been reported that amphibians can smell not only airborne odorants but also aminoacids. It is not clear, however, whether the signal transduction pathway of the amino acid responses is sameas that of volatile odorant responses. In this study, we use patch-clamp recordings of newt olfactory receptorneurons to show that amino acid (200 μM glutamic acid, acidic; 200 μM arginine, basic; 200 μM alanine orcysteine, neutral) responses are accompanied by inducing depolarizing currents. Moreover, responses toboth amino acids and forskolin, a stimulator of adenylate cyclase, were observed in the same cells, whichindicates that the cells responding to amino acids possess the cAMP-system. In addition, our EOG (electroolfactogram)studies show that forskolin attenuates not only responses to volatile odorants, but also those toamino acids. These data provide evidence that the cyclic AMP system might underlie the signal transductionpathway of amino acid responses in addition to volatile odorant responses.
社団法人日本動物学会の論文
2001-03-10