ホヤ心臓の搏動におよぼす薬物の作用, 特にセロトニンの作用について

概要

論文の詳細を見る
The effect of drugs on the heart of Ciona intestinalis has been studied. The animal, the heart of which was exposed by removing the surrounding tissues and pericardial sac, was mounted in a trough filled with sea water flowing in one direction, the heart being ligatured at the middle part to avoid antagonism between the two pacemakers. The drugs were locally applied to the heart surface with a pipette of 300μ diameter. Serotonin (10^<-3>-10^<-5> g/ml) applied to the visceral pacemaker always increased the beating frequency by 8-50% (average 24%). On the other hand, serotonin (10^<-6>-10<-5>) applied to the hypobranchial pacemaker reduced the beating frequency by 8-33% (average 18%) in some animals or showed no effect. The effect was completely reversible. 10^<-9> had no effect. Adrenaline (10^<-6>) increased the frequency of both pacemakers, but had no effect at 10^<-8>-10^<-7> and 10^<-5>. Acetylcholine (10^<-8>-10^<-6>) and GABA (10^<-7>-10^<-5> showed no chronotroic action. The results demonstrate a marked difference in response to serotonin between the two pacemakers over a wide range of concentration. Since serotonin is known to occur in the intestine of Ciona, it is suggested that serotonin might be involved in the regulation of the heart-beat in tunicates.
社団法人日本動物学会の論文
1966-01-15