甲状腺ホルモンの過剰または減少の際のネズミの子宮に対する黄体ホルモンの効果

概要

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1. In hyper- (thyroxine injected) and hypothyroid (methylthiouracil injected) ovariectomized rats receiving daily injections of 0.25 mg. progesterone for 9 days, traumatization of uterine horns on the 5th day of injection caused some enlargement of the stimulated portions of the uterus, but failed to induce any definite decidual reaction. 2. Deciduomata of approximately equal size were produced in both hyper-and hypothyroid ovariectomized rats as well as in euthyroid controls receiving daily injections of 1 mg. progesterone. 3. If ovariectomized rats were injected with 0.03mg. of estrone daily for 4 days prior to the treatment with 0.75mg. progesterone daily for 9 days, traumatization of uterine horns on the 5th day of progesterone injection invariably resulted in the formation of deciduomata. However, deciduomata were largest in hyperthyroid rats and smallest in hypothyroid rats, those in euthyroid ovariectomized rats being intermediate in size. 4. In ovariectomized rats receiving no progesterone, deciduomata were not formed following traumatization of uterine horns. 5. It seems likely that hyperthyroidism enhances the effect of progesterone on the uterus while hypothyroidism suppresses it.
社団法人日本動物学会の論文
1960-10-15