MTK肉腫IIIにおける転移腫瘤の形成に関する細胞組織学的研究(予報)

概要

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The course of the formation of the solid-tumor in Omentum gastrolienis was observed in rats which received intraperitoneal inoculation of the MTK-sarcoma III. The distribution of reticular fibres in the solid tumor was also investigated using the silver-impregnation method. The results of observations are summarized as follows. The metastatic invasion of tumor cells into the omentum takes place directly from the ascites through the mesothelium of the omentum. Then the tumor cells undergo repeated multiplications, with a mitotic frequency similar to that of the ascities tumor. The omentum-tubules containing tumor cells come together into large masses. Following the development of solid tumors the tumor cells come to invade blood vessels and pancreas. In the latter part of a transplant generation the solid tumors show necrotic tumor cells which increase in number with day. The larger part of the solid tumor consists of necrotic cells at the death of the host. The fine network of reticular fibres appears in the solid tumor; the network becomes denser in structure with day. They undergo disintegration along with the degeneration of tumor cells.
社団法人日本動物学会の論文
1956-08-15