脾臓内移植卵巣からの性ホルモン逸出

概要

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In intrasplenic ovarian grafts in gonadecomized rats massive luteinization takes place due to enhancement of the hypophysial gonadotropic activity characterized by an increased secretion of LH. If any estrogen produced by such grafts escapes hepatic inactivation and enters the general circulation, the threshold dose of estradiol-17β given by injection for inducing epithelium cornification in vaginae in situ, or in subcutaneous vaginal grafts, would be smaller in graft-bearing rats in gonadectomized rats without grafts. This was ascertained by the present experiments. When injected subcutaneously for 7 consecutive days, the daily threshold dose of estradiol-17β was 0.05μg in gonadectomized rats and 0.02μg in graft-bearing rats. The finding to indicate that estrogen approximately equivalent to, or less than 0.3μg estradiol-17β, may reach the systemic circulation from the grafts every day. Uteri increased in weight with the stimulation of vaginal epithelium. The weight of adrenals was larger in female rats than in male rats even after administration of estrogen. Ovarian grafts in gonadectomized males and females were similar in histological structure. In gonadectomized rats bearing successful intrasplenic ovarian grafts, a small amount of estrogen can enter the systemic blood and may exert a suppressive effect on the secretion of gonadotropins from the adenohypophysis.
社団法人日本動物学会の論文
1965-09-15