骨格筋単一筋線維におけるカフエイン拘縮
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Experiments were made on single muscle fibres isolated from frog legs in an attempt to elucidate more precisely the mechanism of the contracture induced by a nondepolarizing agent. In normal Ringer's solution, three types of contracture were induced by caffeine (1×10^<-3> w/v); the first was composed of a phasic contracture followed by irregularly sustained, and much less, tension. The second was induced in relatively fine fibres and was of only a slow component. The third was of a phasic contracture followed by a gradually developing one which resulted in rigor. It was also demonstrated that the maximum tensions of these contractures, induced in normal solution, were proportional to the cross-sectional areas of fibres. In Ca-deficient muscle fibre soaked in Ca-free Ringer's solution, caffeine produced exactly the same contracture as in normal solution, whereas in Ca-deprived muscle fibre soaked in Ca-free Ringer's containing 4mM EDTA, caffeine produced less tension. In depolarized fibre soaked in K_2SO_4-Ringer's, caffeine produced the same as or less tension than in normal solution. In fibre soaked in Ca-free K_2SO_4-Ringer's solution, caffeine induced contracture in 2 or 3min. In fibre soaked in KCl-Ringer's solution, caffeine induced much less contracture than that in K_2SO_4-Ringer's and in fibre kept in Ca-free KCl-Ringer's, little or no contracture was induced by caffeine. These results suggest that bound Ca in muscle plays some role in initiating caffeine-induced contracture.
- 社団法人日本動物学会の論文
- 1965-06-15
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